evaluation of the effects of intravenous ascorbic acid on correction of anemia in renal failure patients undergoing hemodialysis

نویسندگان

محمد رحیمیان

m rahimian . non علی اصغر شجاعی

aa shojaie

چکیده

introduction: hemodialysis patients often develop resistance to recombinant human erythropoietin due to functional iron deficiency. in these patients iron therapy can be hazardous leading to hemosiderosis. recent studies have suggested that intravenous ascorbic acid may be able to improve this hyporeponsiveness. the aim of this study was to evaluate the effect of intravenous ascorbic acid on functional iron deficiency and whether it results in better correction of anemia or not. methods: forty hemodialysis patients with serum ferritin >300ug/l, hemoglobin less than 10 gm/dl, and transferrin saturation less than 20% were selected. the reticulocyte index and kt/v was also calculated. patients were later administered 500 mg intravenous ascorbic acid three times a week for three months. at the end of study, serum ferritin, transferrin saturation, hemoglobin, reticulocyte index and kt/v were rechecked and compared with the base line values by before and after method. results: serum ferritin decreased significantly (median base line ferritin 480.45 ug/dl as compared to final ferritin level of 363.78 (p=0.0001), whereas there was a significant rise in hemoglobin concentration (median baseline hemoglobin 8.92 gm/dl compared to 9.88gm/dl (p=0.0001). transferrin saturation was also significantly raised (median baseline transferrin saturation 17.35% as compared to final level of 25.12% (p= 0.0001). kt/v before and after treatment with ascorbic acid had no significant change (p =0.396). finally, the rate of decrease in serum ferritin and increase in hemoglobin according to age and duration of dialysis was studied. the effect of ascorbic acid was found to be significantly greater in older patients and those with longer duration of dialysis (p <0.05) but there was no significant relationship between transferrin saturation increase and age or duration of dialysis. conclusion: intravenous ascorbic acid may partially correct functional iron deficiency, although anemia is not totally corrected.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

the effects of error correction methods on pronunciation accuracy

هدف از انجام این تحقیق مشخص کردن موثرترین متد اصلاح خطا بر روی دقت آهنگ و تاکید تلفظ کلمه در زبان انگلیسی بود. این تحقیق با پیاده کردن چهار متد ارائه اصلاح خطا در چهار گروه، سه گروه آزمایشی و یک گروه تحت کنترل، انجام شد که گروه های فوق الذکر شامل دانشجویان سطح بالای متوسط کتاب اول passages بودند. گروه اول شامل 15، دوم 14، سوم 15 و آخرین 16 دانشجو بودند. دوره مربوطه به مدت 10 هفته ادامه یافت و د...

15 صفحه اول

the effects of changing roughness on the flow structure in the bends

flow in natural river bends is a complex and turbulent phenomenon which affects the scour and sedimentations and causes an irregular bed topography on the bed. for the reason, the flow hydralics and the parameters which affect the flow to be studied and understand. in this study the effect of bed and wall roughness using the software fluent discussed in a sharp 90-degree flume bend with 40.3cm ...

The Effect of Dignity Therapy on Human Dignity in Patients with Chronic Renal Failure Undergoing Hemodialysis

Background: Chronic renal failure is a life-threatening condition; patients due to the prolonged stress are very susceptible to mental health problems. Dignity therapy is a novel therapeutic approach to the treatment of psychological problems for patients who suffer from life-threatening illnesses. Aim: This study examined the impact of dignity therapy on human dignity in patients undergoing he...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
مجله دانشگاه علوم پزشکی شهید صدوقی یزد

جلد ۱۴، شماره ۱، صفحات ۳-۸

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023